Trying to conceive (TTC) is a big issue. At least 90 million couples worldwide, 11 million in the US alone, are trying to become pregnant. With only a 20% average chance of becoming pregnant each cycle, it's no surprise that couples can become stressed.

Intercourse on demand around ovulation can lead to anxiety and increased vaginal dryness. In fact, 75% of TTC couples report an increased frequency of vaginal dryness.

In relieving vaginal dryness, couples do not want to create another problem. However, most personal lubricants and even saliva can harm sperm.  Research conducted on personal lubricants over the past three decades has clearly demonstrated their detrimental effects on sperm (Figure 1).

Since Pre-Seed® was first introduced in 2002, other lubricant products claiming to be “fertility- or conception-friendly” have been introduced. However, a recent study found that only Pre-Seed’s® formula did not impact the ability of sperm to fertilize or support normal embryo development, where as several other “fertility” lubricants caused a decline in fertilization and embryo growth rates in an animal model.

* p < 0.05 & ** p < 0.0001 compared to control

Pre’® by INGfertility, shares the same formula as Pre~Seed®
PreConceivePlus will no longer be sold in the US after July 2009. As advertised "Conceive Plus was PreConceive Plus" and is still sold by Sasmar Australia Pty., ConceiveEase by Sepal Reproductive Devices

Additionally, none of these other lubricants have 510(k) clearance by FDA with labeling for use during fertility interventions, or as safe for use by couples who are trying to conceive (Learn More).

Replens® is a product of Lil' Drug Store® Products, Inc.
Astroglide® is a product of BioFilm, Inc.
K-Y® is a product of McNeil-PPC, Inc.
Pre~Seed® is a product of INGfertility, LLC
PreConceive Plus now ConceivePlus is a product of Sasmar
ConceivEase is a product of Sepal Reproductive Devices

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